BRD4 silencing attenuates hemin-induced neuronal ferroptosis and inflammation via the H3K27ac–ATF3 axis in an in vitro model of cerebral hemorrhage

BRD4 silencing attenuates hemin-induced neuronal ferroptosis and inflammation via the H3K27ac–ATF3 axis in an in vitro model of cerebral hemorrhage

Abstract Background Intracerebral hemorrhage (ICH), a subtype of hemorrhagic stroke, is associated with high morbidity and mortality. This study aimed to investigate the role and underlying mechanism of bromodomain and extraterminal domain protein 4 (BRD4) in neural injury following ICH. Methods An...

Full description

Saved in:
Bibliographic Details
Main Authors: Jing Yi, Hua Tang, Siwei Que, Tao Zheng, Hu Zeng, Xiaoming Xie, Hua Chen
Format: Article
Language:English
Published: BMC 2025-07-01
Series:European Journal of Medical Research
Subjects:
Intracerebral hemorrhage
Ferroptosis
Inflammation
BRD4
H3K27ac
ATF3
Online Access:https://doi.org/10.1186/s40001-025-02759-1
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s40001-025-02759-1

Similar Items