Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells

Targeting mitochondrial metabolism by the mitotoxin bromoxib in leukemia and lymphoma cells

Abstract Targeting mitochondrial metabolism represents a promising approach for cancer treatment. Here, we investigated the mitotoxic potential of the polybrominated diphenyl ether bromoxib, a natural compound isolated from the marine sponge Dysidea family. We could show that bromoxib comprised stro...

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Bibliographic Details
Main Authors: Laura Schmitt, Karina S. Krings, Andre Wolsing, Xabier Buque, Marcel Zimmermann, Hector Flores-Romero, Thomas Lenz, Ilka Lechtenberg, Christoph Peter, Björn Stork, Nicole Teusch, Peter Proksch, Kai Stühler, Ana J. García-Sáez, Andreas S. Reichert, Patricia Aspichueta, Sanil Bhatia, Sebastian Wesselborg
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Cell Communication and Signaling
Subjects:
OXPHOS
Metabolism
Protonophore
Leukemia
Online Access:https://doi.org/10.1186/s12964-024-01913-2
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https://doi.org/10.1186/s12964-024-01913-2

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