Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

Alzheimer-mutant γ-secretase complexes stall amyloid β-peptide production

Missense mutations in the amyloid precursor protein (APP) and presenilin-1 (PSEN1) cause early-onset familial Alzheimer’s disease (FAD) and alter proteolytic production of secreted 38-to-43-residue amyloid β-peptides (Aβ) by the PSEN1-containing γ-secretase complex, ostensibly supporting the amyloid...

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Bibliographic Details
Main Authors: Parnian Arafi, Sujan Devkota, Emily Williams, Masato Maesako, Michael S Wolfe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
proteolysis
secretase
mass spectrometry
fluorescence microscopy
Online Access:https://elifesciences.org/articles/102274
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