Transiently elevated expression of different forms of brain-derived neurotrophic factor in the neonatal medial prefrontal cortex affected anxiety and depressive-like behaviors in adolescence

Transiently elevated expression of different forms of brain-derived neurotrophic factor in the neonatal medial prefrontal cortex affected anxiety and depressive-like behaviors in adolescence

Brain-derived neurotrophic factor (BDNF) is a secreted molecule that plays an important role in the survival and growth of nerve cells. BDNF undergoes complex post-translational processing with cellular proteases. Pro- and mature BDNF forms bind to different receptor types in the brain. BDNF is prom...

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Main Authors: Dmitriy Lanshakov, Elizaveta Shaburova, Ekaterina Sukhareva, Veta Bulygina, Uliana Drozd, Irina Larionova, Tatiana Gerashchenko, Tatiana Shnaider, Evgeny V. Denisov, Tatyana Kalinina
Format: Article
Language:English
Published: PeerJ Inc. 2024-11-01
Series:PeerJ
Subjects:
Prefrontal cortex
Neonatal period
Juvenile period
RNAseq
Anxiety
Depression
Online Access:https://peerj.com/articles/18465.pdf
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