Leveraging Omeprazole PBPK/PD Modeling to Inform Drug–Drug Interactions and Specific Recommendations for Pediatric Labeling

Leveraging Omeprazole PBPK/PD Modeling to Inform Drug–Drug Interactions and Specific Recommendations for Pediatric Labeling

<b>Background/Objectives:</b> Omeprazole is widely used for managing gastrointestinal disorders like GERD, ulcers, and <i>H. pylori</i> infections. However, its use in pediatrics presents challenges due to drug interactions (DDIs), metabolic variability, and safety concerns....

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Bibliographic Details
Main Authors: Amira Soliman, Leyanis Rodriguez-Vera, Ana Alarcia-Lacalle, Leandro F. Pippa, Saima Subhani, Viera Lukacova, Jorge Duconge, Natalia V. de Moraes, Valvanera Vozmediano
Format: Article
Language:English
Published: MDPI AG 2025-03-01
Series:Pharmaceutics
Subjects:
PBPK-PD
omeprazole
pediatrics
age-physiological changes
developmental changes
Online Access:https://www.mdpi.com/1999-4923/17/3/373
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