CCR5 blockade inflames antitumor immunity in BAP1-mutant clear cell renal cell carcinoma

CCR5 blockade inflames antitumor immunity in BAP1-mutant clear cell renal cell carcinoma

Background Patients with BRCA1-associated protein 1 (BAP1)-mutant clear cell renal cell carcinoma (ccRCC) have worse prognosis. C-C chemokine receptor 5 (CCR5) plays an important role in ccRCC development and its expression is elevated in BAP1-mutant tumors.Methods 533 patients with ccRCC from The C...

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Main Authors: Li Liu, Quan Zhou, Yangyang Qi, Weijuan Zhang, Jiejie Xu, Yu Xia, Ying Xiong, Yu Zhu, Zewei Wang, Han Zeng, Hongyu Zhang, Zhaopei Liu, Qiuren Huang, Jiajun Wang, Yuan Chang, Yiwei Wang, Le Xu, Bo Dai, Qi Bai, Jianming Guo
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/8/1/e000228.full
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