MCAM interacts with integrin β1 to promote EGFR-TKI resistance in lung adenocarcinoma through the JAK3 signalling pathway

MCAM interacts with integrin β1 to promote EGFR-TKI resistance in lung adenocarcinoma through the JAK3 signalling pathway

Abstract Background Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have exhibited remarkable efficacy against EGFR-mutated lung cancer. However, the majority of patients receiving EGFR-TKIs face a grim prognosis due to acquired drug resistance. Melanoma cell adhesion molec...

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Main Authors: Saiqun Zhang, Yuling Chen, Chang Li, Jian Zhao, Min Jiao, Mengzhu Zhang, Chenkang Ma, Anqi Wang, Jianjun Li, Yuanyuan Zeng, Jianjie Zhu, Chuanyong Mu, Jian-an Huang, Zeyi Liu
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Journal of Translational Medicine
Subjects:
EGFR-TKIs
MCAM
Integrin β1
JAK3
Resistance
Online Access:https://doi.org/10.1186/s12967-025-06874-9
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https://doi.org/10.1186/s12967-025-06874-9

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