Insulin‐like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

Insulin‐like growth factor 2 reverses memory and synaptic deficits in APP transgenic mice

Abstract Insulin‐like growth factor 2 (IGF2) was recently found to play a critical role in memory consolidation in rats and mice, and hippocampal or systemic administration of recombinant IGF2 enhances memory. Here, using a gene therapy‐based approach with adeno‐associated virus (AAV), we show that...

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Main Authors: Maria Pascual‐Lucas, Silvia Viana da Silva, Marianna Di Scala, Carolina Garcia‐Barroso, Gloria González‐Aseguinolaza, Christophe Mulle, Cristina M Alberini, Mar Cuadrado‐Tejedor, Ana Garcia‐Osta
Format: Article
Language:English
Published: Springer Nature 2014-08-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
IGF1
IGF2
IGF2R
synaptic plasticity
Online Access:https://doi.org/10.15252/emmm.201404228
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https://doi.org/10.15252/emmm.201404228

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