DETERMINATION OF A BIOLOGICALLY ACTIVE COMPOUND OF KON- 1 IN BLOOD PLASMA BY METHOD OF HIGH-PERFOMANCE LIQUID CHROMATOGRAPHY WITH MINIMUM SAMPLE PRETREATMENTPROCEDURE: DEVELOPMENT AND VALIDATION OF THE METHOD, USE IN PRE-CLINICAL PHARMACOKINETIC RESEARCHES

The aim of this work was the development and validation of methods for determination of biologically active compound KOH-1 with proven nootropic activity in blood plasma by high performance liquid chromatography (HPLC) with ultraviolet detection (HPLC-UV). A simple, rapid and unlaborious procedure w...

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Bibliographic Details
Main Authors: E. A. Bulgakova, Yu. N. Karpenko
Format: Article
Language:Russian
Published: Federal State Autonomous Educational Institution of Higher Education I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University) 2018-03-01
Series:Сеченовский вестник
Subjects:
Online Access:https://www.sechenovmedj.com/jour/article/view/53
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