Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents
Abstract Background Both psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children and adolescents are diseases of transient loss of consciousness. It is difficult to distinguish them clinically. This paper will study the differential diagnostic value of P wave dispersion (Pd) and QT i...
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2025-01-01
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| Series: | Italian Journal of Pediatrics |
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| Online Access: | https://doi.org/10.1186/s13052-025-01864-5 |
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| author | Zifeng Huang Yi Xu Shuo Wang Ping Liu Xingfang Zen Yuwen Wang Fang Li Runmei Zou Cheng Wang |
| author_facet | Zifeng Huang Yi Xu Shuo Wang Ping Liu Xingfang Zen Yuwen Wang Fang Li Runmei Zou Cheng Wang |
| author_sort | Zifeng Huang |
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| description | Abstract Background Both psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children and adolescents are diseases of transient loss of consciousness. It is difficult to distinguish them clinically. This paper will study the differential diagnostic value of P wave dispersion (Pd) and QT interval dispersion (QTd) between PPS and VVS. Methods The 31 children with PPS and 40 children with VVS from July 2014 to November 2023 were enrolled as the study group. Meanwhile, 30 healthy children who underwent a physical examination at the same hospital were matched to the control group. P wave duration and QT interval in the 12-lead electrocardiogram were measured at the baseline. Results (1) Comparison between groups: ① The Pd, corrected P wave dispersion (Pcd), QTd, and corrected QT interval dispersion (QTcd) in PPS group were significantly higher than those in control group (P < 0.05). The minimum P wave duration (Pmin) and corrected P wave duration (Pcmin) in PPS group were significantly lower than those in control group (P < 0.05). There were no significant differences in maximum P wave duration (Pmax), corrected maximum P-wave duration (Pcmax), maximum QT interval (QTmax), minimum QT interval (QTmin), corrected maximum QT interval (QTcmax), and corrected minimum QT interval (QTcmin) between PPS group and control group (P > 0.05). ② The Pd, Pcd, QTd, and QTcd in VVS group were significantly higher than those in control group (P < 0.05). The Pmin, Pcmin, and QTcmin in VVS group were significantly lower than those in control group (P < 0.05). There were no significant differences in Pmax, Pcmax, QTmax, QTmin, and QTcmax between VVS group and control group (P > 0.05). ③ The Pmax, Pd, QTmax, QTd, and QTcd in PPS group were significantly lower than those in VVS group (P < 0.05). There were no significant differences in Pmin, Pcmax, Pcmin, Pcd, QTmin, QTcmax, and QTcmin between PPS group and VVS group (P > 0.05). (2) ROC curve: Pmax, Pd, QTmax, QTd, and QTcd had a certain differential diagnostic value between PPS and VVS in children and adolescents (P < 0.05). QTd had the largest area under curve (0.735), with a sensitivity of 85.00% and a specificity of 53.30% at the cut off value of ≥ 28.11 ms for VVS diagnosis. Conclusions In children and adolescents, electrocardiogram parameters such as Pmax, Pd, QTmax, QTd, and QTcd all possess predictive value in differentiating between PPS and VVS. Among them, QTd has the greatest differential diagnostic value. |
| format | Article |
| id | doaj-art-9125132c974a4c5680421bb246a73967 |
| institution | Kabale University |
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| language | English |
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| series | Italian Journal of Pediatrics |
| spelling | doaj-art-9125132c974a4c5680421bb246a739672025-01-26T12:45:10ZengBMCItalian Journal of Pediatrics1824-72882025-01-015111810.1186/s13052-025-01864-5Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescentsZifeng Huang0Yi Xu1Shuo Wang2Ping Liu3Xingfang Zen4Yuwen Wang5Fang Li6Runmei Zou7Cheng Wang8Department of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatrics, Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityDepartment of Pediatric Cardiovasology, Children’s Medical Center, The Second Xiangya Hospital, Central South UniversityAbstract Background Both psychogenic pseudosyncope (PPS) and vasovagal syncope (VVS) in children and adolescents are diseases of transient loss of consciousness. It is difficult to distinguish them clinically. This paper will study the differential diagnostic value of P wave dispersion (Pd) and QT interval dispersion (QTd) between PPS and VVS. Methods The 31 children with PPS and 40 children with VVS from July 2014 to November 2023 were enrolled as the study group. Meanwhile, 30 healthy children who underwent a physical examination at the same hospital were matched to the control group. P wave duration and QT interval in the 12-lead electrocardiogram were measured at the baseline. Results (1) Comparison between groups: ① The Pd, corrected P wave dispersion (Pcd), QTd, and corrected QT interval dispersion (QTcd) in PPS group were significantly higher than those in control group (P < 0.05). The minimum P wave duration (Pmin) and corrected P wave duration (Pcmin) in PPS group were significantly lower than those in control group (P < 0.05). There were no significant differences in maximum P wave duration (Pmax), corrected maximum P-wave duration (Pcmax), maximum QT interval (QTmax), minimum QT interval (QTmin), corrected maximum QT interval (QTcmax), and corrected minimum QT interval (QTcmin) between PPS group and control group (P > 0.05). ② The Pd, Pcd, QTd, and QTcd in VVS group were significantly higher than those in control group (P < 0.05). The Pmin, Pcmin, and QTcmin in VVS group were significantly lower than those in control group (P < 0.05). There were no significant differences in Pmax, Pcmax, QTmax, QTmin, and QTcmax between VVS group and control group (P > 0.05). ③ The Pmax, Pd, QTmax, QTd, and QTcd in PPS group were significantly lower than those in VVS group (P < 0.05). There were no significant differences in Pmin, Pcmax, Pcmin, Pcd, QTmin, QTcmax, and QTcmin between PPS group and VVS group (P > 0.05). (2) ROC curve: Pmax, Pd, QTmax, QTd, and QTcd had a certain differential diagnostic value between PPS and VVS in children and adolescents (P < 0.05). QTd had the largest area under curve (0.735), with a sensitivity of 85.00% and a specificity of 53.30% at the cut off value of ≥ 28.11 ms for VVS diagnosis. Conclusions In children and adolescents, electrocardiogram parameters such as Pmax, Pd, QTmax, QTd, and QTcd all possess predictive value in differentiating between PPS and VVS. Among them, QTd has the greatest differential diagnostic value.https://doi.org/10.1186/s13052-025-01864-5Psychogenic pseudosyncopeVasovagal syncopeP wave dispersionQT interval dispersionChildrenAdolescent |
| spellingShingle | Zifeng Huang Yi Xu Shuo Wang Ping Liu Xingfang Zen Yuwen Wang Fang Li Runmei Zou Cheng Wang Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents Italian Journal of Pediatrics Psychogenic pseudosyncope Vasovagal syncope P wave dispersion QT interval dispersion Children Adolescent |
| title | Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents |
| title_full | Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents |
| title_fullStr | Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents |
| title_full_unstemmed | Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents |
| title_short | Differential diagnostic value of P wave dispersion and QT interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents |
| title_sort | differential diagnostic value of p wave dispersion and qt interval dispersion between psychogenic pseudosyncope and vasovagal syncope in children and adolescents |
| topic | Psychogenic pseudosyncope Vasovagal syncope P wave dispersion QT interval dispersion Children Adolescent |
| url | https://doi.org/10.1186/s13052-025-01864-5 |
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