Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations

Adjunctive beneficial effect of c-di-GMP, a STING agonist, in enhancing protective efficacy of TLR4-adjuvanted tuberculosis subunit vaccine formulations

Abstract Background Effective subunit vaccine development requires selecting appropriate adjuvant formulations to trigger desired adaptive immune responses. This study explores the immunogenicity and tuberculosis (TB) vaccine potential of antigens (Ags) combined with Toll-like receptor 4 (TLR4) adju...

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Bibliographic Details
Main Authors: Kee Woong Kwon, Eunsol Choi, Hagyu Kim, Hyeong Woo Kim, Sangwon Choi, Seunghyun Lee, Sang-Jun Ha, Sung Jae Shin
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Biomedical Science
Subjects:
Tuberculosis
Mycobacterium tuberculosis
Subunit vaccine
TLR4 adjuvant
STING agonist
c-di-GMP
Online Access:https://doi.org/10.1186/s12929-025-01144-8
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https://doi.org/10.1186/s12929-025-01144-8

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