Distinct effects of adjuvants on B cell responses to protein or polysaccharide antigens contained in glycoconjugate vaccines

Distinct effects of adjuvants on B cell responses to protein or polysaccharide antigens contained in glycoconjugate vaccines

BackgroundProtein-polysaccharide conjugate vaccines rely on the induction of T-cell-dependent responses that support germinal center (GC) reactions to potentiate the expansion of antigen-specific memory B-cell (MBC) populations and high-avidity antibody responses. The effects of adjuvants on B-cell...

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Main Authors: Sonia Budroni, Elisa Faenzi, Simona Tavarini, Chiara Sammicheli, Francesca Buricchi, Gianfranco Volpini, Erica Borgogni, Fabiana Spensieri, Evita Balducci, Bruno Galletti, Maria Rosaria Romano, Ugo D’Oro, Oretta Finco, Monia Bardelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Immunology
Subjects:
polysaccharide
vaccine
adjuvant
memory B cells
avidity
mice
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574941/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1574941/full

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