The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases

The role of cGAS-STING pathway ubiquitination in innate immunity and multiple diseases

The cGAS-STING pathway is essential in innate immunity, especially in antiviral responses and cellular stress management. cGAS acts as a cytoplasmic DNA sensor by initiating the synthesis of the second messenger cyclic GMP-AMP synthase (cGAMP), which subsequently activates the STING pathway, leading...

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Bibliographic Details
Main Authors: Chunyan Deng, Dongyan Chen, Liang Yang, Yubiao Zhang, Cheng Jin, Yue Li, Qihong Lin, Mingjing Luo, Ruihao Zheng, Baozhen Huang, Sixi Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
CGAS
STING
ubiquitination
innate immunity
cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1522200/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1522200/full

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