Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor

Head and neck squamous cell carcinoma-derived extracellular vesicles mediate Ca²⁺-dependent platelet activation and aggregation through tissue factor

Abstract Background Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, characterized by poor clinical outcomes, primarily driven by high rate of locoregional recurrence and metastasis. Extensive heterogeneity among the tumor cells as well as modulation of a highly immunosuppr...

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Main Authors: Tobias Weiser, Cosima C. Hoch, Julie Petry, Maria Shoykhet, Benedikt Schmidl, Mina Yazdi, Khouloud Hachani, Julia Mergner, Marie-Nicole Theodoraki, Omid Azimzadeh, Gabriele Multhoff, Ali Bashiri Dezfouli, Barbara Wollenberg
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Cell Communication and Signaling
Subjects:
Coagulation cascade
Cancer-associated thrombosis
Head and neck squamous cell carcinoma
Platelet activation
Extracellular vesicles
Tissue factor
Online Access:https://doi.org/10.1186/s12964-025-02215-x
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https://doi.org/10.1186/s12964-025-02215-x

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