Gut microbiota dysbiosis and disturbed tryptophan metabolism mediate cognitive impairment in mice with circadian rhythm disruption

Gut microbiota dysbiosis and disturbed tryptophan metabolism mediate cognitive impairment in mice with circadian rhythm disruption

Circadian rhythm disorder (CRD) is a risk factor for cognitive deficits, yet its mechanisms remain unclear. We previously found CRD model mice developed cognitive impairment mediated through gut microbiota disturbance, intestinal barrier damage, and microglia activation, but the signaling pathway wa...

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Bibliographic Details
Main Authors: Haiyue Song, Huiliang Zhang, Xuan Qin, Yi Liu, Yiwen Lai, Wenqi Yang, Lun Zhang, Wenting Hu, Xiaochuan Wang, Ji Zeng, Rong Liu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
Circadian rhythm disruption
Cognitive deficit
Gut microbiota
Gut metabolites
Tryptophan
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002850
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