Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Abstract Bilirubin, an endogenous metabolite with many significant physiological roles, particularly anti‐inflammatory properties, shows great promise as a treatment for inflammatory diseases. However, the binding targets and downstream signaling mechanisms of bilirubin remain unclear. Here, by usin...

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Main Authors: Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li
Format: Article
Language:English
Published: Wiley 2025-08-01
Series:Advanced Science
Subjects:
bilirubin
neuroinflammation
NLRP3
phosphorylation
WNK kinase
Online Access:https://doi.org/10.1002/advs.202407349
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https://doi.org/10.1002/advs.202407349

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