Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening

Identification of β4GALNT2 as an anti-hPIV3 factor through genome-wide CRISPR/Cas9 library screening

Human respirovirus 3 (also known as human parainfluenza virus 3; hPIV3) is a major cause of severe acute respiratory infections in vulnerable populations. Here we conducted a genome-wide CRISPR/Cas9 library screen to identify key host factors for hPIV3 infection. In addition to identifying several h...

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Bibliographic Details
Main Authors: Xuesheng Wu, Rutger D. Luteijn, Estefanía Lozano-Andrés, Katherine Marougka, Wentao Li, Yoshiki Narimatsu, Frank J. M. van Kuppeveld, Berend Jan Bosch, Robert Jan Lebbink, Erik de Vries, Cornelis A. M. de Haan
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Emerging Microbes and Infections
Subjects:
Paramyxovirus
CRISPR/Cas9
B4GALNT2
hPIV3
virus entry
sialic acid
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2025.2529895
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https://www.tandfonline.com/doi/10.1080/22221751.2025.2529895

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