DNFE: Directed network flow entropy for detecting tipping points during biological processes.

Typically, in dynamic biological processes, there is a critical state or tipping point that marks the transition from one stable state to another, surpassing which a considerable qualitative shift takes place. Identifying this tipping point and its driving network is essential to avert or delay disa...

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Bibliographic Details
Main Authors: Xueqing Peng, Rui Qiao, Peiluan Li, Luonan Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-07-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1013336
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