Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer

Abstract Castration-resistant prostate cancer is a heterogeneous disease with variable phenotypes commonly observed in later stages of the disease. These include cases that retain expression of luminal markers and those that lose hormone dependence and acquire neuroendocrine features. While there ar...

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Main Authors: Kei Mizuno, Sheng-Yu Ku, Varadha Balaji Venkadakrishnan, Martin K. Bakht, Michael Sigouros, Joanna Chan, Anna Trigos, Jordan H. Driskill, Jyothi Manohar, Abigail King, Adam G. Presser, Min Jin Kim, Alok K. Tewari, Henry W. Long, David Quigley, Toni K. Choueiri, Steven Balk, Sarah Hill, Juan Miguel Mosquera, David Einstein, Shahneen Sandhu, Mary-Ellen Taplin, Himisha Beltran
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60654-z
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https://doi.org/10.1038/s41467-025-60654-z

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