Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress‐CAF to Promote Chordoma Progression via Targeting ITGB1

Hypoxic Upregulation of IER2 Increases Paracrine GMFG Signaling of Endoplasmic Reticulum Stress‐CAF to Promote Chordoma Progression via Targeting ITGB1

Abstract Currently, the oncogenic mechanism of endoplasmic reticulum stress‐CAF (ERS‐CAF) subpopulation in chordoma remains unknown. Here, single‐cell RNA sequencing, spatial transcriptomics, GeoMx Digital Spatial Profiler, data‐independent acquisition proteomics, bulk RNA‐seq, and multiplexed quant...

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Main Authors: Tao‐Lan Zhang, Bo‐Wen Zheng, Chao Xia, Peng‐Fei Wu, Bo‐Yv Zheng, Ling‐Xiang Jiang, Jing Li, Guo‐Hua Lv, Hong Zhou, Wei Huang, Ming‐Xiang Zou
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Advanced Science
Subjects:
cancer‐associated fibroblasts
chordoma progression
endoplasmic reticulum stress
hypoxia
IER2/GMFG/ITGB1 axis
paracrine
Online Access:https://doi.org/10.1002/advs.202405421
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https://doi.org/10.1002/advs.202405421

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