FGFR4 p.Gly388Arg polymorphism in PBMCs of LAM patients: findings of a pilot study

Lymphangioleiomyomatosis (LAM) is a rare, progressive lung disease characterized by neoplastic-like proliferation of abnormal smooth muscle–like cells, primarily driven by mutations in the TSC2 gene. These mutations result in hyperactivation of the mTOR signaling pathway, leading to uncontrolled cel...

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Bibliographic Details
Main Authors: Sinem Koc-Gunel, Amy L. Ryan, Melanie Winter, Thomas O. F. Wagner
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1544910/full
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