Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice

Small intestinal γδ T17 cells promote SAE through STING/C1q-induced microglial synaptic pruning in male mice

Abstract Sepsis is a severe global health issue with high mortality rates, and sepsis-associated encephalopathy (SAE) further exacerbates this risk. While recent studies have shown the migration of gut immune cells to the lungs after sepsis, their impact on the central nervous system remains unclear...

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Main Authors: Yuming Wu, Yujing Zhang, Yuan Yu, Xin Wang, Zifan Zhen, Yin Yuan, Bing Xie, Mengqi Han, Mengyuan Wang, Xinyu Zhang, Xueqiang Sun, Xiaoyue Wen, Kenji Hashimoto, You Shang, Shiying Yuan, Jiancheng Zhang
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62181-3
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https://doi.org/10.1038/s41467-025-62181-3

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