The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D-Galactosamine-Sensitized Mouse Model of Lethal Shock

The Therapeutic Efficacy of MS473, a Fully Human Single-Chain Variable Fragment Targeting Staphylococcus aureus Toxic Shock Syndrome Toxin-1, in a D-Galactosamine-Sensitized Mouse Model of Lethal Shock

Abstract Toxic shock syndrome toxin-1 (TSST-1), produced by Staphylococcus aureus, is one of the most potent superantigens involved in causing life-threatening TSS and contributes to the onset of some autoimmune diseases. To this end, we have previously identified a fully human single-chain variable...

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Bibliographic Details
Main Authors: Fatemeh Rahimi-Jamnani, Hamid Reza Moradi, Abolfazl Fateh, Masoumeh Azizi, Farzaneh Nazari, Mahdieh Soezi, Seyed Davar Siadat
Format: Article
Language:English
Published: BMC 2025-02-01
Series:BMC Microbiology
Subjects:
Staphylococcus aureus
Toxic shock syndrome
Superantigens
Toxic shock syndrome toxin-1
Single-chain variable fragment
Online Access:https://doi.org/10.1186/s12866-025-03825-8
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https://doi.org/10.1186/s12866-025-03825-8

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