Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine
Background: We have previously shown that the anti-neoplastic agent erucylphosphohomocholine (ErPC3) requires the mitochondrial 18 kDa Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), to induce cell death via the mitochondrial apoptosis pathway.
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2008-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.3233/CLO-2008-0431 |
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| _version_ | 1849693171172245504 |
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| author | Wilfried Kugler Leo Veenman Yulia Shandalov Svetlana Leschiner Ilana Spanier Max Lakomek Moshe Gavish |
| author_facet | Wilfried Kugler Leo Veenman Yulia Shandalov Svetlana Leschiner Ilana Spanier Max Lakomek Moshe Gavish |
| author_sort | Wilfried Kugler |
| collection | DOAJ |
| description | Background: We have previously shown that the anti-neoplastic agent erucylphosphohomocholine (ErPC3) requires the mitochondrial 18 kDa Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), to induce cell death via the mitochondrial apoptosis pathway. |
| format | Article |
| id | doaj-art-904e896a6810457a88e37814efcfc55f |
| institution | DOAJ |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2008-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-904e896a6810457a88e37814efcfc55f2025-08-20T03:20:30ZengWileyCellular Oncology1570-58701875-86062008-01-0130543545010.3233/CLO-2008-0431Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to ErucylphosphohomocholineWilfried Kugler0Leo Veenman1Yulia Shandalov2Svetlana Leschiner3Ilana Spanier4Max Lakomek5Moshe Gavish6Abteilung Pädiatrie I, Zentrum Kinderheilkunde und Jugendmedizin, Universitätsklinikum Göttingen, D-37075 Göttingen, GermanyDepartment of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, IsraelDepartment of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, IsraelDepartment of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, IsraelDepartment of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, IsraelAbteilung Pädiatrie I, Zentrum Kinderheilkunde und Jugendmedizin, Universitätsklinikum Göttingen, D-37075 Göttingen, GermanyDepartment of Pharmacology, Rappaport Family Institute for Research in the Medical Sciences, Technion–Israel Institute of Technology, Haifa, IsraelBackground: We have previously shown that the anti-neoplastic agent erucylphosphohomocholine (ErPC3) requires the mitochondrial 18 kDa Translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor (PBR), to induce cell death via the mitochondrial apoptosis pathway.http://dx.doi.org/10.3233/CLO-2008-0431 |
| spellingShingle | Wilfried Kugler Leo Veenman Yulia Shandalov Svetlana Leschiner Ilana Spanier Max Lakomek Moshe Gavish Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine Cellular Oncology |
| title | Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine |
| title_full | Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine |
| title_fullStr | Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine |
| title_full_unstemmed | Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine |
| title_short | Ligands of the Mitochondrial 18 kDa Translocator Protein Attenuate Apoptosis of Human Glioblastoma Cells Exposed to Erucylphosphohomocholine |
| title_sort | ligands of the mitochondrial 18 kda translocator protein attenuate apoptosis of human glioblastoma cells exposed to erucylphosphohomocholine |
| url | http://dx.doi.org/10.3233/CLO-2008-0431 |
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