IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

IRE1α promotes phagosomal calcium flux to enhance macrophage fungicidal activity

Summary: The mammalian endoplasmic reticulum (ER) stress sensor inositol-requiring enzyme 1α (IRE1α) is essential for cellular homeostasis and plays key roles in infection responses, including innate immunity and microbicidal activity. While IRE1α functions through the IRE1α-XBP1S axis are known, it...

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Main Authors: Michael J. McFadden, Mack B. Reynolds, Britton C. Michmerhuizen, Einar B. Ólafsson, Sofia M. Marshall, Faith Anderson Davis, Tracey L. Schultz, Takao Iwawaki, Jonathan Z. Sexton, Mary X.D. O’Riordan, Teresa R. O’Meara
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Cell Reports
Subjects:
CP: Immunology
CP: Microbiology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725004656
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