Fasting activates optineurin-mediated mitophagy in chondrocytes to protect against osteoarthritis
Abstract Mitochondrial homeostasis plays a crucial role in the pathogenesis of osteoarthritis (OA), a chronic musculoskeletal disorder characterized by articular cartilage degeneration and chondrocyte apoptosis. However, molecular mechanisms underlying the association between mitophagy and OA remain...
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Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2025-01-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-025-07541-x |
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