Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated children

Prenatal exposures and cell type proportions are main drivers of FKBP5 DNA methylation in maltreated and non-maltreated children

DNA methylation in peripheral tissues may be a relevant biomarker of risk for developing mental disorders after exposure to early life adversity. Genes involved in HPA axis regulation, such as FKBP5, might play a key role. In this study, we aimed to identify the main drivers of salivary FKBP5 methyl...

Full description

Saved in:
Bibliographic Details
Main Authors: Vera N. Karlbauer, Jade Martins, Monika Rex-Haffner, Susann Sauer, Simone Roeh, Katja Dittrich, Peggy Doerr, Heiko Klawitter, Sonja Entringer, Claudia Buss, Sibylle M. Winter, Christine Heim, Darina Czamara, Elisabeth B. Binder
Format: Article
Language:English
Published: Elsevier 2024-11-01
Series:Neurobiology of Stress
Subjects:
DNA methylation
Early-life adversity
Glucocorticoids
FKBP5
HAM-TBS
Online Access:http://www.sciencedirect.com/science/article/pii/S2352289524000833
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S2352289524000833

Similar Items