Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections

Streptococcus pyogenes pharyngitis elicits diverse antibody responses to key vaccine antigens influenced by the imprint of past infections

Abstract Knowledge gaps regarding human immunity to Streptococcus pyogenes have impeded vaccine development. To address these gaps and evaluate vaccine candidates, we established a human challenge model of S. pyogenes pharyngitis. Here, we analyse antibody responses in serum and saliva against 19 an...

Full description

Saved in:
Bibliographic Details
Main Authors: Joshua Osowicki, Hannah R. Frost, Kristy I. Azzopardi, Alana L. Whitcombe, Reuben McGregor, Lauren H. Carlton, Ciara Baker, Loraine Fabri, Manisha Pandey, Michael F. Good, Jonathan R. Carapetis, Mark J. Walker, Pierre R. Smeesters, Paul V. Licciardi, Nicole J. Moreland, Danika L. Hill, Andrew C. Steer
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54665-5
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1038/s41467-024-54665-5

Similar Items