Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1

Hippo pathway activation mediates cardiomyocyte ferroptosis to promote dilated cardiomyopathy through downregulating NFS1

Cardiomyocyte loss by regulated death modes, like apoptosis and ferroptosis, has been implicated in the development of dilated cardiomyopathy (DCM). It remains unclear whether cardiomyocyte ferroptosis occurs as a consequence of Hippo pathway activation. Using a mouse model of DCM by overexpression...

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Main Authors: Gang She, Xia-Xia Hai, Li-Ye Jia, Yong-Jian Zhang, Yu-Jie Ren, Zheng-Da Pang, Lin-Hong Wu, Meng-Zhuan Han, Yu Zhang, Jing-Jing Li, Ru-Yue Bai, Bao-Chang Lai, Yi-Yi Yang, Junichi Sadoshima, Xiao-Jun Du, Xiu-Ling Deng, Yi Zhang
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
Dilated cardiomyopathy
Hippo pathway
Ferroptosis
NFS1
Iron-sulfur cluster
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001107
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