Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke

Synergistic Network Pharmacology: Preclinical Validation and Clinical Safety in Acute Ischemic Stroke

Background Most human disease definitions, except for rare and communicable diseases, are based on symptoms in specific organs, not on causal molecular mechanisms. This limits treatments to imprecise symptomatic approaches with high numbers needed to treat. Systems medicine, instead, has a holistic...

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Main Authors: Ana I. Casas, Cristian Nogales, Rebecca D. Szepanowski, Mahmoud H. Elbatreek, Elisa Anastasi, Sepideh Sadegh, James Skelton, Benedikt Frank, Anil Wipat, Jan Baumbach, Christoph Kleinschnitz, Harald H. H. W. Schmidt
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
diabetes
ischemic stroke
network pharmacology
safety trial
systems medicine
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.039098
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https://www.ahajournals.org/doi/10.1161/JAHA.124.039098

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