Evasion of immunosurveillance by the upregulation of Siglec15 in bladder cancer

Evasion of immunosurveillance by the upregulation of Siglec15 in bladder cancer

Abstract Immunotherapy resistance in bladder cancer (BLCA) is associated with elevated levels of sialic acid–binding immunoglobulin-like lectin (Siglec15). This protein plays a crucial role in fostering a noninflammatory tumor microenvironment (TME), which is conducive to cancer progression. Our stu...

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Main Authors: Dingshan Deng, Jiatong Xiao, Jinhui Liu, Huihuang Li, Minghui Hu, Bohan Zhou, Haisu Liang, Benyi Fan, Jinbo Chen, Xiaogen Kuang, Zhenyu Nie, Jiao Hu, Xiongbing Zu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Journal of Hematology & Oncology
Subjects:
Siglec15
Bladder cancer
Immunotherapy
Noninflamed tumor microenvironment
Online Access:https://doi.org/10.1186/s13045-024-01638-2
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https://doi.org/10.1186/s13045-024-01638-2

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