Interobserver variability in her2 immunohistochemistry analysis and its clinical implications with the advent of the HER2-low category

Interobserver variability in her2 immunohistochemistry analysis and its clinical implications with the advent of the HER2-low category

Abstract Background HER2 protein expression levels are determined by immunohistochemistry (IHQ) and has been classified as positive (3 + or 2+/ in situ hybridization positive) or negative (0, 1 + or 2+/ in situ hybridization negative) because only positive cases had the possibility of targeted thera...

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Bibliographic Details
Main Authors: Ana Catharina Joaquim, Lucas Kliemann Bazzaneze, Ana Paula Percicote, Ana Paula Martins Sebastião
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Surgical and Experimental Pathology
Subjects:
HER2
Trastuzumab-deruxtecan
Variation
Interobserver
Immunohistochemistry
Online Access:https://doi.org/10.1186/s42047-025-00199-z
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https://doi.org/10.1186/s42047-025-00199-z

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