Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease

Colonic epithelial-derived FGF1 drives intestinal stem cell commitment toward goblet cells to suppress inflammatory bowel disease

Abstract Understanding the molecular mechanisms that regulate intestinal epithelial cell (IEC) renewal provides potential targets for inflammatory bowel disease (IBD). Growing evidence has highlighted the importance of epithelial signals in regulating intestinal stem cell (ISC) differentiation. Howe...

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Main Authors: Qian Lin, Sudan Zhang, Jiaren Zhang, Yi Jin, Taoli Chen, Ruoyu Lin, Jiaxuan Lv, Wenjing Xu, Tianzhen Wu, Shenyu Tian, Lei Ying, Xiaokun Li, Zhifeng Huang, Jianlou Niu
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58644-2
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https://doi.org/10.1038/s41467-025-58644-2

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