SKI regulates rRNA transcription and pericentromeric heterochromatin to ensure centromere integrity and genome stability

SKI regulates rRNA transcription and pericentromeric heterochromatin to ensure centromere integrity and genome stability

Accurate chromosome segregation and ribosomal gene expression silencing are essential for maintaining genome integrity, and disruptions in these processes are key for oncogenesis and cancer progression. Here, we demonstrate a novel role for the transcriptional co-repressor SKI in regulating rDNA and...

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Bibliographic Details
Main Authors: Víctor Pola-Véliz, David Carrero, Eduardo A. Sagredo, Víctor Inostroza, Claudio Cappelli, Solange Rivas, Mirit Bitrán, Evelyn Zambrano, Evelin Gonzalez, Fernanda Morales, Marcia Manterola, Martín Montecino, Ricardo Armisén, Katherine Marcelain
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
SKI
rRNA
Pericentromeric heterochromatin
Chromosomal Instability
Breast cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558625000843
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http://www.sciencedirect.com/science/article/pii/S1476558625000843

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