A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.

The RNA exosome is an evolutionarily-conserved ribonuclease complex critically important for precise processing and/or complete degradation of a variety of cellular RNAs. The recent discovery that mutations in genes encoding structural RNA exosome subunits cause tissue-specific diseases makes defini...

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Main Authors: Derrick J Morton, Binta Jalloh, Lily Kim, Isaac Kremsky, Rishi J Nair, Khuong B Nguyen, J Christopher Rounds, Maria C Sterrett, Brianna Brown, Thalia Le, Maya C Karkare, Kathryn D McGaughey, Shaoyi Sheng, Sara W Leung, Milo B Fasken, Kenneth H Moberg, Anita H Corbett
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-07-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008901&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1008901&type=printable

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