TnSeq identifies genetic requirements of Mycobacterium tuberculosis for survival under vaccine-induced immunity

Abstract Mycobacterium tuberculosis (Mtb), the etiologic agent of tuberculosis (TB), remains a persistent global health challenge due to the lack of an effective vaccine. The only licensed TB vaccine, Bacille Calmette-Guerin (BCG), is a live attenuated strain of Mycobacterium bovis that protects you...

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Bibliographic Details
Main Authors: Kimra S. James, Neharika Jain, Kelly Witzl, Nico Cicchetti, Sarah M. Fortune, Thomas R. Ioerger, Amanda J. Martinot, Allison F. Carey
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01150-9
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