Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

Exploring the heterodimer MDM2/MDM4 interaction region uncovers high-affinity peptides for therapeutic p53-reactivation

IntroductionIn the era of targeted therapies, molecules for the reactivation of the oncosuppressor p53 in human cancer have not yet reached FDA or EMA approval. Recently, the interaction region of the MDM2/MDM4 heterodimer, the most efficient inhibitor of p53 levels and function, has been successful...

Full description

Saved in:
Bibliographic Details
Main Authors: Marika Attili, Sonia Valentini, Maria Pesavento, Marco Ballarotto, Viviana Scognamiglio, Alfredo Pontecorvi, Antonio Macchiarulo, Fulvio Saccoccia, Fabiola Moretti
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Chemical Biology
Subjects:
target p53
peptide
MDM2
MDM4 (MDMX)
umbrella sampling
Online Access:https://www.frontiersin.org/articles/10.3389/fchbi.2025.1576640/full
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.frontiersin.org/articles/10.3389/fchbi.2025.1576640/full

Similar Items