The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish.

The transcription factors Tfeb and Tfe3 are required for survival and embryonic development of pancreas and liver in zebrafish.

The transcription factors TFEB and TFE3 modulate expression of lysosomal, autophagic, and metabolic genes to restore energy and cellular homeostasis in response to a variety of stress conditions. Since their role during vertebrate development is less characterized, we used CRISPR/Cas9 to deplete tfe...

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Main Authors: Alberto Rissone, Martina La Spina, Erica Bresciani, Zulfeqhar A Syed, Christian A Combs, Martha Kirby, Abdel Elkahloun, Vicky Chen, Raman Sood, Shawn M Burgess, Rosa Puertollano
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-06-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1011754
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https://doi.org/10.1371/journal.pgen.1011754

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