Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites

Suppression by RNA Polymerase I Inhibitors Varies Greatly Between Distinct RNA Polymerase I Transcribed Genes in Malaria Parasites

The transcription of ribosomal RNA (rRNA) by RNA Polymerase I (Pol I) is the rate-limiting step in ribosome biogenesis and a major determinant of cellular growth rates. Unlike other eukaryotes, which express identical rRNA from large tandem arrays of dozens to hundreds of identical rRNA genes in eve...

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Bibliographic Details
Main Authors: Hermela Samuel, Riward Campelo Morillo, Björn F. C. Kafsack
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pathogens
Subjects:
RNA Polymerase I
transcription
inhibitors
non-coding RNA
ribosomal RNA
malaria parasites
Online Access:https://www.mdpi.com/2076-0817/13/11/924
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