Pentamidine inhibition of streptopain attenuates Streptococcus pyogenes virulence

ABSTRACT The obligate human pathogen Streptococcus pyogenes (also known as GAS; Group A Streptococcus) carries high morbidity and mortality, primarily in impoverished or resource-poor regions. The failure rate of monotherapy with conventional antibiotics is high, and invasive infections by this bact...

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Bibliographic Details
Main Authors: Keya Trivedi, Christopher N. LaRock
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00758-25
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