Photobleaching alters the morphometric analysis of fluorescently labeled neurons and microglial cells

Photobleaching of immunofluorescence signal is a well-known phenomenon, however, its impact on derived parameters characterizing number and shape of different cell types in tissue sections is less understood. Our aim was to determine whether the duration of illumination and the type of fluorophore (...

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Bibliographic Details
Main Authors: Tamás F. Polgár, Krisztina Spisák, Zalán Kádár, Nora Alodah, Gabor J. Szebeni, Kata Klein, Roland Patai, László Siklós, Bernát Nógrádi
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Pathology and Oncology Research
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Online Access:https://www.por-journal.com/articles/10.3389/pore.2025.1612087/full
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