Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates
Abstract Neonatal hyperbilirubinemia is a prevalent condition during the neonatal period, and in severe instances, it can result in brain damage accompanied by irreversible neurological consequences. Therefore, early detection and intervention are paramount. This research aimed to detect early-stage...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-88007-2 |
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| author | Shuang He Meiyu Wang Man Zhu Min Zhang Xueni He Xiang Jiang Shu Tang Zhaoxia Wang |
| author_facet | Shuang He Meiyu Wang Man Zhu Min Zhang Xueni He Xiang Jiang Shu Tang Zhaoxia Wang |
| author_sort | Shuang He |
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| description | Abstract Neonatal hyperbilirubinemia is a prevalent condition during the neonatal period, and in severe instances, it can result in brain damage accompanied by irreversible neurological consequences. Therefore, early detection and intervention are paramount. This research aimed to detect early-stage brain damage resulting from neonatal hyperbilirubinemia through the application of two-dimensional cranial ultrasound and microvascular blood flow (MV-Flow) imaging techniques. Clinical data, along with gray-scale and microvascular ultrasound images of the basal ganglia, were collected from 85 neonates (hyperbilirubinemia group vs. non-hyperbilirubinemia group: 51 vs. 34). The Globus Pallidus to Putamen (G/P) ratio and the vascular index (VIMV) were calculated. A comparative analysis of clinical and ultrasonographic data between the groups was conducted. The hyperbilirubinemia group had higher mean G/P ratios (1.39 ± 0.49 vs. 1.16 ± 0.12, P < 0.05) and lower VIMV, which was negatively correlated with TSB levels (coronal: r = -0.419, P < 0.05; parasagittal: r = -0.448, P < 0.05). Cranial gray-scale ultrasound demonstrates altered gray values in the basal ganglia region, and the MV-Flow technique reveals and quantifies the microvascular structure of this region. These methods may serve as potential biological markers for the early assessment of bilirubin-induced brain damage. |
| format | Article |
| id | doaj-art-8f539c5343fb429a9dc6a580bf84d09a |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-8f539c5343fb429a9dc6a580bf84d09a2025-02-02T12:22:45ZengNature PortfolioScientific Reports2045-23222025-02-0115111210.1038/s41598-025-88007-2Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonatesShuang He0Meiyu Wang1Man Zhu2Min Zhang3Xueni He4Xiang Jiang5Shu Tang6Zhaoxia Wang7Department of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical UniversityDepartment of Pediatrics, Shulan (Jinan) HospitalDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical UniversityDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical UniversityDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical UniversityDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical UniversityKey Laboratory of Computer Network and Communications Technology, Chongqing University of Posts and TelecommunicationsDepartment of Ultrasound, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Children’s Hospital of Chongqing Medical UniversityAbstract Neonatal hyperbilirubinemia is a prevalent condition during the neonatal period, and in severe instances, it can result in brain damage accompanied by irreversible neurological consequences. Therefore, early detection and intervention are paramount. This research aimed to detect early-stage brain damage resulting from neonatal hyperbilirubinemia through the application of two-dimensional cranial ultrasound and microvascular blood flow (MV-Flow) imaging techniques. Clinical data, along with gray-scale and microvascular ultrasound images of the basal ganglia, were collected from 85 neonates (hyperbilirubinemia group vs. non-hyperbilirubinemia group: 51 vs. 34). The Globus Pallidus to Putamen (G/P) ratio and the vascular index (VIMV) were calculated. A comparative analysis of clinical and ultrasonographic data between the groups was conducted. The hyperbilirubinemia group had higher mean G/P ratios (1.39 ± 0.49 vs. 1.16 ± 0.12, P < 0.05) and lower VIMV, which was negatively correlated with TSB levels (coronal: r = -0.419, P < 0.05; parasagittal: r = -0.448, P < 0.05). Cranial gray-scale ultrasound demonstrates altered gray values in the basal ganglia region, and the MV-Flow technique reveals and quantifies the microvascular structure of this region. These methods may serve as potential biological markers for the early assessment of bilirubin-induced brain damage.https://doi.org/10.1038/s41598-025-88007-2Cranial UltrasoundMV-FlowHyperbilirubinemiaNeonatal |
| spellingShingle | Shuang He Meiyu Wang Man Zhu Min Zhang Xueni He Xiang Jiang Shu Tang Zhaoxia Wang Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates Scientific Reports Cranial Ultrasound MV-Flow Hyperbilirubinemia Neonatal |
| title | Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates |
| title_full | Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates |
| title_fullStr | Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates |
| title_full_unstemmed | Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates |
| title_short | Exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates |
| title_sort | exploring the feasibility and clinical impact of ultrasound microvascular flow imaging in detecting brain injury in hyperbilirubinemia neonates |
| topic | Cranial Ultrasound MV-Flow Hyperbilirubinemia Neonatal |
| url | https://doi.org/10.1038/s41598-025-88007-2 |
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