Topical tacrolimus for the amelioration of breast cancer-related lymphedema (TACLE Trial): a study protocol for a randomized, double-blind, placebo-controlled phase II/III trial

Topical tacrolimus for the amelioration of breast cancer-related lymphedema (TACLE Trial): a study protocol for a randomized, double-blind, placebo-controlled phase II/III trial

Abstract Background Breast cancer-related lymphedema is a chronic condition affecting 15–30% of breast cancer patients, resulting from treatment-related inflammation and fibrosis primarily mediated by CD4 + T-cells. Tacrolimus, an immunomodulator, has shown efficacy in reducing lymphedema in both an...

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Bibliographic Details
Main Authors: Frederik Gulmark Hansen, Mads Gustaf Jørgensen, Jørn Bo Thomsen, Jens Ahm Sørensen
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Trials
Subjects:
Breast cancer-related lymphedema
Breast cancer
Tacrolimus
Inflammation
Quality of life
Randomized controlled trial
Online Access:https://doi.org/10.1186/s13063-025-08829-3
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https://doi.org/10.1186/s13063-025-08829-3

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