Engineering a controlled cardiac multilineage co-differentiation process using statistical design of experiments

Abstract Background The heart is a complex organ composed of diverse cell types, whose interplay is crucial for development, tissue homeostasis, and disease progression. A potential approach to recapitulate this heterotypic multicellular environment is the co-differentiation of induced pluripotent s...

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Bibliographic Details
Main Authors: Hirokazu Akiyama, Yosuke Katayama, Kazunori Shimizu, Hiroyuki Honda
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Stem Cell Research & Therapy
Subjects:
Online Access:https://doi.org/10.1186/s13287-025-04408-0
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