Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice

Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice

Abstract Short-term preoperative methionine restriction (MetR) is a promising translatable strategy to mitigate surgical injury response. However, its application to improve post-interventional vascular remodeling remains underexplored. Here we find that MetR protects from arterial intimal hyperplas...

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Main Authors: Peter Kip, Thijs J. Sluiter, Michael R. MacArthur, Ming Tao, Nicky Kruit, Sarah J. Mitchell, Jonathan Jung, Sander Kooijman, Josh Gorham, Jonathan G. Seidman, Paul H. A. Quax, Julius L. Decano, Masanori Aikawa, C. Keith Ozaki, James R. Mitchell, Margreet R. de Vries
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53844-8
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https://doi.org/10.1038/s41467-024-53844-8

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