The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study
Abstract Background Arteriosclerosis significantly impacts cardiovascular health. Pulse wave velocity has emerged as a valuable non-invasive method for assessing arterial stiffness. A negative association between carotid-femoral pulse wave velocity (cfPWV) and cerebral blood flow has been reported,...
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BMC
2024-07-01
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| Series: | Artery Research |
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| Online Access: | https://doi.org/10.1007/s44200-024-00053-9 |
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| author | Salahaden R. Sultan |
| author_facet | Salahaden R. Sultan |
| author_sort | Salahaden R. Sultan |
| collection | DOAJ |
| description | Abstract Background Arteriosclerosis significantly impacts cardiovascular health. Pulse wave velocity has emerged as a valuable non-invasive method for assessing arterial stiffness. A negative association between carotid-femoral pulse wave velocity (cfPWV) and cerebral blood flow has been reported, suggesting a link between arterial stiffness and reduced cerebral blood flow. We aimed to determine whether a correlation exists between cfPWV and blood flow in the internal carotid artery (ICA) and to assess the influence of age and body mass index (BMI) on cfPWV in healthy individuals. Methods Thirty-six healthy subjects (23 males and 13 females) with no underlying medical conditions and who were not on regular medications were enrolled in the study. Arterial stiffness was assessed by measuring the cfPWV using Vicorder® software. ICA blood flow parameters were measured using high-resolution ultrasound. ICA diameter was measured using automated edge-detection software. Results Significant positive correlations were found between cfPWV and age (Spearman’s rho coefficient 0.33, p = 0.04), BMI (Spearman’s rho coefficient 0.32, p = 0.05), and ICA diameter (Pearson’s coefficient 0.35, p = 0.03). No significant correlations were observed between cfPWV and ICA peak systolic velocities (PSV; p = 0.22), or resistive index (RI; p = 0.76), nor between age and ICA diameter (p = 0.42), PSV (p = 0.09), or RI (p = 0.89). Conclusion Our findings demonstrate a positive correlation between arterial stiffness, age, and BMI in a healthy population, along with an association between increased ICA diameter and arterial stiffness. The lack of correlation between cfPWV and ICA blood flow parameters suggests that the ICA may dilate as a compensatory mechanism to mitigate the effects of increased arterial stiffness, ensuring optimal cerebral blood flow in healthy individuals. |
| format | Article |
| id | doaj-art-8f20fa45559b4cb6aa3e1fb17d8b75a2 |
| institution | Kabale University |
| issn | 1876-4401 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | BMC |
| record_format | Article |
| series | Artery Research |
| spelling | doaj-art-8f20fa45559b4cb6aa3e1fb17d8b75a22025-02-02T12:14:51ZengBMCArtery Research1876-44012024-07-013011810.1007/s44200-024-00053-9The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot StudySalahaden R. Sultan0Department of Radiologic Sciences, Faculty of Applied Medical Sciences, King Abdulaziz UniversityAbstract Background Arteriosclerosis significantly impacts cardiovascular health. Pulse wave velocity has emerged as a valuable non-invasive method for assessing arterial stiffness. A negative association between carotid-femoral pulse wave velocity (cfPWV) and cerebral blood flow has been reported, suggesting a link between arterial stiffness and reduced cerebral blood flow. We aimed to determine whether a correlation exists between cfPWV and blood flow in the internal carotid artery (ICA) and to assess the influence of age and body mass index (BMI) on cfPWV in healthy individuals. Methods Thirty-six healthy subjects (23 males and 13 females) with no underlying medical conditions and who were not on regular medications were enrolled in the study. Arterial stiffness was assessed by measuring the cfPWV using Vicorder® software. ICA blood flow parameters were measured using high-resolution ultrasound. ICA diameter was measured using automated edge-detection software. Results Significant positive correlations were found between cfPWV and age (Spearman’s rho coefficient 0.33, p = 0.04), BMI (Spearman’s rho coefficient 0.32, p = 0.05), and ICA diameter (Pearson’s coefficient 0.35, p = 0.03). No significant correlations were observed between cfPWV and ICA peak systolic velocities (PSV; p = 0.22), or resistive index (RI; p = 0.76), nor between age and ICA diameter (p = 0.42), PSV (p = 0.09), or RI (p = 0.89). Conclusion Our findings demonstrate a positive correlation between arterial stiffness, age, and BMI in a healthy population, along with an association between increased ICA diameter and arterial stiffness. The lack of correlation between cfPWV and ICA blood flow parameters suggests that the ICA may dilate as a compensatory mechanism to mitigate the effects of increased arterial stiffness, ensuring optimal cerebral blood flow in healthy individuals.https://doi.org/10.1007/s44200-024-00053-9Arterial stiffnessPulse wave velocityPWVInternal carotid arteryBlood flow |
| spellingShingle | Salahaden R. Sultan The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study Artery Research Arterial stiffness Pulse wave velocity PWV Internal carotid artery Blood flow |
| title | The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study |
| title_full | The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study |
| title_fullStr | The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study |
| title_full_unstemmed | The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study |
| title_short | The Association of Arterial Pulse Wave Velocity with Internal Carotid Artery Blood Flow in Healthy Subjects: A Pilot Study |
| title_sort | association of arterial pulse wave velocity with internal carotid artery blood flow in healthy subjects a pilot study |
| topic | Arterial stiffness Pulse wave velocity PWV Internal carotid artery Blood flow |
| url | https://doi.org/10.1007/s44200-024-00053-9 |
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