GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

Objective: Gemcitabine combined with nab-paclitaxel therapy (GnP) represents first-line chemotherapy for advanced pancreatic ductal adenocarcinoma (PDAC). However, the efficacy of GnP is diminished due to chemotherapeutic resistance induced by the tumor microenvironment (TME), the underlying mechani...

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Bibliographic Details
Main Authors:	Tianyi Zhu, Qianwen Yang, Xiaozhe Qian, Xiuqi Wu, Jianchen Fang, Yuli Lin, Yukuan Feng, Jian Gao, Qing Xia
Format:	Article
Language:	English
Published:	China Anti-Cancer Association 2025-07-01
Series:	Cancer Biology & Medicine
Subjects:	pancreatic ductal adenocarcinoma gnp resistance neutrophil extracellular traps gprc5a tumor microenvironment
Online Access:	https://www.cancerbiomed.org/content/22/7/832
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