GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

GPRC5A/CXCL8/NLRP3-mediated neutrophil extracellular traps drive gemcitabine-nab-paclitaxel resistance in pancreatic adenocarcinoma

Objective: Gemcitabine combined with nab-paclitaxel therapy (GnP) represents first-line chemotherapy for advanced pancreatic ductal adenocarcinoma (PDAC). However, the efficacy of GnP is diminished due to chemotherapeutic resistance induced by the tumor microenvironment (TME), the underlying mechani...

Full description

Saved in:
Bibliographic Details
Main Authors: Tianyi Zhu, Qianwen Yang, Xiaozhe Qian, Xiuqi Wu, Jianchen Fang, Yuli Lin, Yukuan Feng, Jian Gao, Qing Xia
Format: Article
Language:English
Published: China Anti-Cancer Association 2025-07-01
Series:Cancer Biology & Medicine
Subjects:
pancreatic ductal adenocarcinoma
gnp resistance
neutrophil extracellular traps
gprc5a
tumor microenvironment
Online Access:https://www.cancerbiomed.org/content/22/7/832
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://www.cancerbiomed.org/content/22/7/832

Similar Items