Evaluation of safety and efficacy of multiple intravenous and intraosseous doses of foetal liver-derived mesenchymal stem cells in children with severe osteogenesis imperfecta: the BOOST2B clinical trial protocol

Evaluation of safety and efficacy of multiple intravenous and intraosseous doses of foetal liver-derived mesenchymal stem cells in children with severe osteogenesis imperfecta: the BOOST2B clinical trial protocol

Aims: Current off-label bisphosphonate treatment for osteogenesis imperfecta (OI) does not induce healthy bone formation. Therefore, novel strategies to stimulate osteogenesis and reduce fractures are needed to meet the medical needs of these patients. Preclinical data and case studies show that mu...

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Main Authors: Vrisha Madhuri, Sowmya Ramesh, Annika Goos, Thomas V. Paul, Shyamkumar Nidugala Kesava, Vikram Mathews, Lilian Walther-Jallow, Cecilia Götherström, on behalf of the BOOST2B Study Group
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2025-03-01
Series:Bone & Joint Open
Subjects:
paediatric clinical trial
bone injection
stem cell therapy
genetic abnormality
collagen mutation
bone formation
osteogenesis imperfecta
intraosseous
mesenchymal stem cells (mscs)
clinical studies
blood
bone mineral density (bmd)
long bones
bone turnover
body weight
Online Access:https://online.boneandjoint.org.uk/doi/epdf/10.1302/2633-1462.63.BJO-2024-0115.R1
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https://online.boneandjoint.org.uk/doi/epdf/10.1302/2633-1462.63.BJO-2024-0115.R1

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