Steroid Avoidance in Liver Transplantation
Corticosteroids have always played a valuable role in transplantation. Unfortunately, they are subject to a wide range of side effects, such as hyperlipidemia, hypertension, diabetes mellitus, osteoporosis, growth retardation and Cushingoid appearance. Steroids may also exacerbate problems that exis...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2004-01-01
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| Series: | Canadian Journal of Gastroenterology |
| Online Access: | http://dx.doi.org/10.1155/2004/412135 |
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| _version_ | 1832548556909576192 |
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| author | José Oberholzer Mohammed Al-Saghier Norman M Kneteman |
| author_facet | José Oberholzer Mohammed Al-Saghier Norman M Kneteman |
| author_sort | José Oberholzer |
| collection | DOAJ |
| description | Corticosteroids have always played a valuable role in transplantation.
Unfortunately, they are subject to a wide range of side effects, such as
hyperlipidemia, hypertension, diabetes mellitus, osteoporosis, growth
retardation and Cushingoid appearance. Steroids may also exacerbate
problems that existed before surgery, including malignancy, hepatitis B
and hepatitis C. New, powerful immunosuppressants have allowed
steroid use to be reduced or avoided altogether, but use of these regimens
is not simple and may be associated with late acute rejection
and recurrence of autoimmune disease. The present review examines
the rationale for steroid avoidance in liver transplantation and assesses
the new regimens that are currently being developed. |
| format | Article |
| id | doaj-art-8efcd4e5c4704df98e6d9cab0af7ec80 |
| institution | Kabale University |
| issn | 0835-7900 |
| language | English |
| publishDate | 2004-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology |
| spelling | doaj-art-8efcd4e5c4704df98e6d9cab0af7ec802025-02-03T06:13:52ZengWileyCanadian Journal of Gastroenterology0835-79002004-01-0118Suppl C5C11C10.1155/2004/412135Steroid Avoidance in Liver TransplantationJosé Oberholzer0Mohammed Al-Saghier1Norman M Kneteman2Hepatobiliary and Pancreatic Surgery, University of Alberta, Edmonton, Alberta, CanadaHepatobiliary and Pancreatic Surgery, University of Alberta, Edmonton, Alberta, CanadaHepatobiliary and Pancreatic Surgery, University of Alberta, Edmonton, Alberta, CanadaCorticosteroids have always played a valuable role in transplantation. Unfortunately, they are subject to a wide range of side effects, such as hyperlipidemia, hypertension, diabetes mellitus, osteoporosis, growth retardation and Cushingoid appearance. Steroids may also exacerbate problems that existed before surgery, including malignancy, hepatitis B and hepatitis C. New, powerful immunosuppressants have allowed steroid use to be reduced or avoided altogether, but use of these regimens is not simple and may be associated with late acute rejection and recurrence of autoimmune disease. The present review examines the rationale for steroid avoidance in liver transplantation and assesses the new regimens that are currently being developed.http://dx.doi.org/10.1155/2004/412135 |
| spellingShingle | José Oberholzer Mohammed Al-Saghier Norman M Kneteman Steroid Avoidance in Liver Transplantation Canadian Journal of Gastroenterology |
| title | Steroid Avoidance in Liver Transplantation |
| title_full | Steroid Avoidance in Liver Transplantation |
| title_fullStr | Steroid Avoidance in Liver Transplantation |
| title_full_unstemmed | Steroid Avoidance in Liver Transplantation |
| title_short | Steroid Avoidance in Liver Transplantation |
| title_sort | steroid avoidance in liver transplantation |
| url | http://dx.doi.org/10.1155/2004/412135 |
| work_keys_str_mv | AT joseoberholzer steroidavoidanceinlivertransplantation AT mohammedalsaghier steroidavoidanceinlivertransplantation AT normanmkneteman steroidavoidanceinlivertransplantation |